Haworth, Brian T. Sutch, Rebecca M. Romero Objectives To evaluate faculty-led discussion meetings (with about eight students) conducted face-to-face (in-class) or by synchronous, real-time videoconference (online), in a biopharmaceutics course taught in a facilitated problem-based learning (PBL) format. Methods Three methods were used to compare in-class versus online discussion sessions for two semesters. The first method involved three parameters that measured the quality of interactions between faculty (facilitator) and student (Fc–St), participation of students in the discussions (Par), and student–student interactions (St–St). The second method assessed student’s perceptions of the discussions with surveys. The third method mapped the interactions (a sociogram) between faculty (facilitator) and students in a discussion. Results There were significantly lower scores for Par and St–St (P < 0.05)>
Physiological aim and you will pharmacology off curcumin
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Yards. Romero, Ian S Haworth Curcumin is the significant component of the fresh new yellow color out of turmeric, an enthusiastic Indian spruce that’s obtained from the fresh new rhizome of your own exotic plant Curcuma longa, and that belongs to the Zingiberaceae family members. Within this part, i discuss the pharmacological items out-of curcumin and mention the unit angles of these things. We following opinion the new proven and prospective scientific spends away from curcumin. Curcumin is well known over the years as a therapeutic representative, but their system regarding step are detailed. The pharmacological negative effects of curcumin seem to be caused by a great synergism of systems from weak biochemical affairs that have multiple physical objectives inside the interconnected signaling pathways. These targets include enzymes instance cyclooxygenase, lipoxygenase and you will protein kinases, and you may transcription affairs for example NF-?B, STAT and you may Nrf2. Modulation of these particles has an effect on downstream affectors that make the fresh antiinflammatory, anti-oxidant, chemopreventive, anticancer, and you will antimicrobial circumstances regarding curcumin. These types of effects were looked at from inside the scientific trials from curcumin to possess soreness and you will inflammatory disorder, cancer, Alzheimer disease, cardio problems, and you may all forms of diabetes. The brand new samples have used adjustable dosage away from curcuminwith various other wavelengths and you may stage, for the standard end that higher dosages off curcumin at amount of g are required to see therapeutic outcomes. Read more
Curcumin: Synthesis, Emerging Part in the Discomfort Management and you can Health Effects
Guide Chapter Types of plant-derived pharmaceuticals having become the attract from continuous and you will rapid search and you may advancement focus features, up to now, already been quite scarce. Shortly after years, the final two decades was basically characterized by an effective 100-bend boost in just how many medical posts authored a year you to was off advantages towards the accessibility curcumin for the biomedicine. Read more
Build, synthesis and you will physiological activities off curcumin prodrugs
Publication ChapterAsma El-Magboub ,Pornchai Rojsitthisak, Chawanphat Muangnoi, Wisut Wichitnithad, Rebecca Meters. Romero, Ian S Haworth Curcumin has many possible pharmacological consequences that will features healing applications in a lot of disease says, because the chatted about in more detail in the earlier chapter. Although not, the potential scientific efficacy out-of curcumin is bound from the their physicochemical services away from poor drinking water solubility and you can imbalance, and therefore end in low bioavailability. Prodrugs away from curcumin render an easy way to upgrade of biopharmaceutical and pharmacokinetic attributes, and may even ensure it is exploitation of pharmacological ramifications of curcumin. Inside part, i first remark the brand new physicochemical and pharmacokinetics off curcumin. We next identify the style of curcumin prodrugs that have enhanced liquids solubility and improved chemical balance smukke kvinder fra Rumænien which is often translated returning to 100 % free curcumin through to bioactivation in the vivo. We emphasize previous victory in this region, with a focus on the build, synthesis and analysis off prodrugs predicated on promoieties and amino acids, fatty acids, nucleic acids, dicarboxylic acids, and you will polymeric material such as hyaluronic acidic and you may polyethylene glycol. This section has the cause for optimisation of your own physicochemical and biopharmaceutical services therefore the physical activities regarding curcumin prodrugs, toward mission having fun with of them curcumin types within the medical applications. Read more